Broad-Spectrum Cephalosporin-Resistant Klebsiella spp. Isolated from Diseased Horses in Austria

Broad-Spectrum Cephalosporin-Resistant Klebsiella spp. Isolated from Diseased Horses in Austria

Blog Article

The aim of the present study was to investigate the diversity of broad-spectrum cephalosporin-resistant Klebsiella spp.isolated from horses in Austria that originated from diseased horses.A total of seven non-repetitive cefotaxime-resistant Klebsiella sp.

isolates were obtained during diagnostic activities from autumn 2012 to wx gloves October 2019.Antimicrobial susceptibility testing was performed.The isolates were genotyped by whole-genome sequencing (WGS).

Four out of seven Klebsiella isolates were identified as K.pneumoniae, two as K.michiganensis and one as K.

oxytoca.All isolates displayed a multi-drug resistant phenotype.The detection of resistance genes reflected well the phenotypic resistance profiles of the respective isolates.

All but french manicure hydrangea one isolate displayed the extended-spectrum β-lactamases (ESBL) phenotype and carried CTX-M cefotaximases, whereas one isolate displayed an ESBL and AmpC phenotype and carried cephamycinase (CMY)-2 and sulfhydryl variable (SHV)-type b and Temoniera (TEM) β-lactamases.Among Klebsiella pneumoniae isolates, for different sequence types (ST) could be detected (ST147, ST307, ST1228, and a new ST4848).Besides resistance genes, a variety of virulence genes, including genes coding for yersiniabactin were detected.

Considering the high proximity between horses and humans, our results undoubtedly identified a public health issue.This deserves to be also monitored in the years to come.